Graphene Oxide Topical Administration: Skin Permeability Studies
نویسندگان
چکیده
Nanostructured carriers have been widely used in pharmaceutical formulations for dermatological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional formulations. Due to its large surface area, small size photothermal properties, graphene oxide (GO) has the potential be such applications. Nanographene (GOn) presented average sizes of 197.6 ± 11.8 nm, a charge −39.4 1.8 mV, being stable water 6 months. 55.5% mass GOn dispersion (at concentration 1000 µg mL−1) permeated skin after h exposure. dispersions shown absorb near-infrared radiation, reaching temperatures up 45.7 °C, within mild therapy temperature range. Furthermore, amounts superior those which could permeate were not affect human fibroblasts (HFF-1) morphology or viability, 24 incubation. size, no permeation was observed graphite particles aqueous stabilized with Pluronic P-123 (Gt–P-123). Altogether, first time, Gon’s as topic administration agent delivery demonstrated.
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ژورنال
عنوان ژورنال: Materials
سال: 2021
ISSN: ['1996-1944']
DOI: https://doi.org/10.3390/ma14112810